Chronic Conditions & Health

Our goal is to understand causes and consequences of chronic conditions (discovery science), to test if interventions improve health among people with chronic conditions (evaluation science), and to assess ways to implement these findings into real-world programs and policy (implementation science).

 

  ocre  Discovery Science              ocre   Evaluation Science              blue  Implementation Science

 

Accompanying scientific study to the implementation of the “Living well with COPD” program (SELFIS-2)

Anja Frei

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This project aims to assess the effectiveness (level of patients) and the implementation (focus on optimization of the program) of the “Living well with COPD” self-management program, implemented throughout Switzerland by Cantonal Lung Associations.

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AMIS Plus:  National Registry
of Acute Myocardial Infarction
in Switzerland

Dragana Radovanovic

ocre

The AMIS Plus (Acute myocardial Infarction in Switzerland) project is a national registry for patients with acute coronary syndrome (unstable angina and  myocardial infarction).

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ANIMONE: An in vivo data warehouse for neuroscience – biocuration of preclinical research to inform optimization and exploitation of preclinical studies

Benjamin Victor Ineichen

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Using artificial intelligence, we will comprehensively assess rates of bench-to-bedside translation in neuroscience, i.e., how many drugs tested in animals have advanced to treat patients with neurological diseases.

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Better tools for better estimates: Improving approaches to handling missing data in Swiss cancer registries

Sarah Haile

ocre  ocre

We will systematically compare approaches to correcting for missing death information in cancer registries, to reduce bias in resulting survival estimates.

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Cancer incidence in the
Cantons of Zurich & Zug (Cancer Registries)

Sabine Rohrmann

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This project registers patients with newly detected cancer in the cantons of Zurich and Zug in order to compute incidence rates of cancer.

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Can living well save my life? Cancer-protective lifestyle prevalence–and its association with mortality–across Swiss language regions

Sabine Rohrmann

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Do individuals with a healthy lifestyle have a lower risk of dying from cancer?

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Characterization of prevalence, type, treatment, burden of disease and predictors of respiratory symptoms in very prematurely born children in the Zurich area (FLiP)

Susi Kriemler

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The aim of this project is to assess the long-term consequences of very premature birth on respiratory health.

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Communication about Sexuality in COPD (COSY)

Claudia Steurer-Stey

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Sexuality, an important aspect for quality of life (QoL), is overlooked in COPD. We developed an instrument that facilitates communication and counseling about sexuality in persons living with COPD and now perform a randomized controlled trial to assess the effectiveness of a communication intervention.

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COSY Studie: Informationen
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Comparison between two commercially available devices to measure nitric oxide lung diffusing capacity in systemic sclerosis: a randomized crossover trial

Holger Dressel

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This study compares two commercially available devices to measure gas exchange in the lungs of people with systemic sclerosis.

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Descriptive epidemiology and costs of chiropractic care in Switzerland: a nationwide health insurance database analysis

Cesar Hincapié

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This project helps advance fundamental epidemiologic and health economic knowledge of chiropractic care in Switzerland.

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Digital Health Innovation: a Governance Roadmap for Switzerland (D-GOVmap)

Milo Puhan

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This project aims to produce a national policy roadmap for digital health innovation in Switzerland

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Does cardiopulmonary exercise testing provide short-term prognostic information in advanced cystic fibrosis lung disease?

Thomas Radtke /
Helge Hebestreit

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The aim of this international multi-centre study is to determine the prognostic value of cardiopulmonary exercise testing as predictor of short-term death and/or lung transplantation in advanced cystic fibrosis lung disease.

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Does planetary health mean population health? Adherence to a planetary health diet and cancer risk and survival in a prospective cohort study

Sabine Rohrmann

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We evaluate if the risk of cancer is lower in individuals who follow a diet that is both healthy and sustainable with respect to our planet's boundaries.

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Eccentric interval
training in COPD  

Thomas Radtke / Anja Frei

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This study compares two different exercise-training methods in inpatient pulmonary rehabilitation programs in patients with chronic obstructive pulmonary disease (COPD).

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Expert prior elicitation and Bayesian analysis of the association between chiropractic care and acute lumbar disc herniation (LDH) with early surgical intervention

Cesar Hincapié

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Our study objective is to undertake a Bayesian analysis of the association between chiropractic care and acute lumbar disc herniation with early surgical intervention.

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Fusion versus decompression surgery alone for lumbar degenerative spondylolisthesis: a comparative-effectiveness analysis and pragmatic health services assessment

Cesar Hincapié

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Our study provides information about the expected benefit-harm assessment of these surgical treatments in patients with degenerative spondylolisthesis in Switzerland.

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GDM – Gestational Diabetes Mellitus in HIV-infected Women
George Abongomera

Sabine Haller

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This observational study aims to establish a diabetes screening program for Gestational diabetes mellitus (GDM) at the Prevention, Treatment & Care Unit of the Infectious Diseases Institute (IDI) in Kampala, Uganda and ultimately aims to obtain epidemiological data on the prevalence of GDM in HIV positive women.

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Geographic variation in the utilisation of health care interventions: what is the role of recommendations and other influences?
Matthias Schwenkglenks

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We study geographic variation in the healthcare for chronic diseases, related determinant with a special focus on clinical recommendations, and  consequences.

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Health economic aspects of atrial fibrillation: analyses based on the Swiss-AF cohort study

Matthias Schwenkglenks

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We study the cost implications of atrial fibrilation, a frequent heart arrhythmia, and the value-for-money of related treatments, based on data from the Swiss Atrial Fibrillation Cohort Study.

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Holistic and patient-centered triage: Redesigning COPD-management in primary care

Milo Puhan

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The primary aim of our project is to design a triage intervention at the point of primary care to provide palliative care support to COPD patients and their families depending on their COPD-related burden of suffering

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How are feedback and communication strategies best used to communicate results of benchmarking in surgical care?

Cesar Hincapié

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This scoping review maps and synthesises existing evidence on feedback and communication strategies related to benchmarking in surgical practice.

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Knowledge syntheses related to musculoskeletal (MSK) health and care epidemiology

Cesar Hincapié

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We conduct systematic evidence syntheses to inform MSK health and care epidemiology.

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Long Covid in Military Organisations (LoCoMo)

Pat Schlagenhauf

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The  “LoCoMo” study is a prospective, longitudinal cohort study designed to follow-up on 500 tested army personnel who tested either SARS-CoV-2 positive or negative while serving in the Swiss Armed Forces in early 2020.

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Mobilise-D: Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

Milo Puhan

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The European Innovative Medicines Initiatives funded Mobilise-D project aims to develop and implement a digital mobility assessment solution to demonstrate that real-world digital mobility outcomes can successfully predict relevant clinical outcomes and to validate these outcomes in different patient populations.

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Patient Preferences Regarding Benefits and Harms of Advanced Prostate Cancer Treatments in Switzerland

Milo Puhan / Dominik Menges

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We elicit patient preferences regarding the expected benefits and potential harms of the available treatment options in the context of advanced prostate cancer, and explore differences in patient preferences between important population subgroups.

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Predicting a second breast cancer using patient level data

Sabine Rohrmann

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This projects wants to determine if data that are collected at cancer registries on a regular basis can be used to predict whether women with breast cancer are at an increased risk of getting a second breast cancer

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Predictors of long-term work participation among patients with cystic fibrosis undergoing lung transplantation

Thomas Radtke

ocre

The aim of this retrospective study is to assess predictors of long-term work participation among lung transplant recipients with cystic fibrosis.

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PrEP Study: A multicenter, observational cohort to study the characteristics of individuals asking for pre-exposure prophylaxis (PrEP) and the incidence of HIV and STIs: «The Swiss PrEPared Study»

Jan Fehr / Benjamin Hampel

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The SwissPrEPared Study aims to identify the characteristics of individuals asking for pre-exposure prophylaxis (PrEP) and monitor the incidence of HIV and other sexually transmitted infections.

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Prevalence estimation of musculoskeletal conditions in the Global Burden of Disease 2019 Study: critical appraisal of the primary data input studies and an approach to rate the certainty of the GBD modelled epidemiologic estimates

Cesar Hincapié

ocre ocre

Our study helps advance understanding of the primary studies informing GBD modelled metrics and stimulate progress of epidemiological studies of MSK disease burden.

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Risk for neurodegenerative disorders and effectiveness of nonsurgical interventions after mild traumatic brain injury (mTBI)

Cesar Hincapié

ocre ocre

We systematically review and synthesise evidence on the associations between mTBI and neurodegenerative disorders (dementia, Parkinson disease, and amyotrophic lateral sclerosis) and effectiveness of nonsurgical interventions after mTBI.

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Spinal manual therapy versus nerve root injection for the management of primary care patients with lumbar radiculopathy: the SALuBRITY randomized clinical trial.

Cesar Hincapié

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SALuBRITY assesses spinal manual therapy versus nerve root injection for patients with back-related leg pain in primary care to guide treatment decisions and improve patient care.

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Swiss Atrial Fibrillation Cohort 

Matthias Schwenkglenks

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We collect prospective health economic data for the Swiss-Atrial Fibrillation (AF) cohort, a cohort study of Swiss AF patients.

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Swiss chiropractic practice-based research network and musculoskeletal pain patient cohort study: a nationwide, participatory resource to advance musculoskeletal health services research (Swiss ChiCo)

Cesar Hincapié

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Swiss ChiCo develops, gathers, and implements real-world clinical practice information to create the basis for answering a range of MSK healthcare research questions important to patients, clinicians, and policymakers.

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SwissDEM

Anja Frei / Milo Puhan

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The SwissDEM study aims to assess the health condition of elderly people (≥65 years) to ascertain how many people in Switzerland are affected by dementia and how the Corona pandemic affects mental health in this specific age group.

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Swiss MS Registry

Viktor von Wyl

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The Swiss MS Registry is a patient-centered, national research database that aims to comprehensively document aspects of MS that can impact an affected  person's daily live, including social and medical data.

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Systematic evidence syntheses to inform the WHO Guideline on management of chronic primary low back pain in adults.

Cesar Hincapié /Carol Cancelliere

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We conduct systematic evidence syntheses and meta-analyses to inform the World Health Organization guidelines on chronic primary low back pain in adults.

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The fraction of cancer burden attributable to modifiable lifestyle risk factors in Switzerland

Sabine Rohrmann

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We determine the number of cancer cases in Switzerland that are caused by an unhealthy lifestyle, for example by smoking, an unhealthy diet or obesity.

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