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Epidemiology, Biostatistics and Prevention Institute

From single disease reductionist research to informed Machine Learning: A new research paradigm for multimorbidity

Harnessing the vast amounts of observational data available today requires a nuanced approach beyond mere application of machine learning techniques. Effectively decoding such multidimensional problems demands an understanding of not just patterns, but also causality and the processes underlying the data. Traditional reductionist approaches, however, often stumble in the face of high-dimensional complexity. Our aim is to marry these two methodologies, navigating the complexity while anchoring our exploration in robust scientific principles.

One such multifaceted issue is Multimorbidity (i.e., the presence of multiple chronic conditions within an individual patient) is one of the great societal health challenges of our time. The global burden is enormous and multimorbidity is the biggest driver of health care cost. High-quality, actionable research is urgently needed to inform effective, safe and patient-centered care in multimorbid patients.

Our project will develop and implement a much-needed, novel research paradigm bringing together subject knowledge, methods expertise from conventional medical research, Machine Learning (ML) and Mathematics. We seek to deliver innovative, actionable methods to transform the paltry evidence-base while appropriately handling the high degree of complexity in the treatment of patients with multiple chronic conditions. Our consortium consists of leading scientists from Epidemiology (Milo Puhan, Viktor von Wyl, Miquel Serra Burriel), Particle Physics (Nicola Serra), Pharmacoepidemiology (Andrea Burden) and Mathematics (Alessio Figalli, Ashkan Nikeghbali) as well as Medicine (Cynthia Boyd, Oliver Senn, Gregory Lucas), Health Economy (Simon Wieser) and Computer Science (Andrey Ustyuzhanin). The project is hosted the University of Zurich and the Federal Institute of Technology.

We offer up to 6 positions for this exciting project!

PhD position in Epidemiology:
The focus of this position will be on the development methods and applications for causal inference and benefit harm balance modelling in the area of treatments for patients with chronic conditions. Candidates should have a MSc degree in epidemiology, biostatistics, econometrics or another field that brings together data science and subject knowledge. A strong interest for quantitative methods and collaborating across fields is required.

PhD position in Pharmacoepidemiology:
Within this PhD position, the candidate will work with large population-based healthcare data to evaluate polypharmacy patterns and drug-drug interaction risks among patients with multimorbidity. The successful candidate will work on developing and comparing machine learning causal inference models to conventional epidemiologic study designs. Candidates applying for this PhD position should hold a Masters degree in pharmacoepidemiology, epidemiology, biostatistics, public health, pharmacy or another relevant field. Strong communication skills and ability to collaborate with interdisciplinary researchers is required. Additionally, prior experience with machine learning is desirable.

PhD and/or Postdoc positions at the Department of Mathematics of ETH and Department of Physics of UZH:
These positions will concentrate on the data analysis and machine learning aspects of the project. Candidates applying for the PhD position should hold a degree in Mathematics, Physics, or Computer Science and possess experience with deep learning technologies. An eagerness to delve into complex, interdisciplinary research and a passion for understanding and applying machine learning to real-world problems are essential. As for the Postdoctoral position, applicants are expected to have a robust background in the theoretical and mathematical aspects of deep learning and on the application of deep learning to the real-world data. A proven record of strong publications on the topic is essential. We are seeking individuals who are passionate about their work, have a strong commitment to research excellence, and can contribute meaningfully to our team's collective knowledge and expertise.

If you're an ambitious researcher, eager to contribute to a pioneering project, and excel in a team-driven environment, we look forward to receiving your application.

Application Details and Contact Information:
All PhD students will be enrolled in the PhD program Epidemiology & Biostatistics of the Life Science Zurich Graduate School (LSZGS).

Applications should be sent by July 1, 2023 through the portal of the LSZGS.
The start of the positions is in late 2023 or upon agreement. For questions about the positions please contact:
Milo Puhan (Epidemiology)
Andrea Burden (Pharmacoepidemiology)
Nico Serra (Machine Learning)
Alessio Figalli (Mathematics)

Weiterführende Informationen

Team

Milo Puhan (UZH, Co-Project-Lead)
Nico Serra (UZH, Co-Project-Lead
Andrea Burden (ETH,  Co-Project-Lead)
Alessio Figalli (ETH, Co-Project-Lead)
Jakob Burgstaller
Cynthia Boyd
Lucas Gregory
Ashkan Nikeghbali
Oliver Senn
Miqul Serra-Burriel
Andrey Ustyuzhanin
Viktor von Wyl
Simon Wieser
Henock Yebyo

Funding