Swiss-AF is a prospective cohort study of Swiss atrial fibrillation patients, coordinated by the University of Basel and funded by the Swiss National Foundation. The cohort aims to generate new insights into the interrelationships between atrial fibrillatiobn, structural brain alterations and cognitive decline, in a long-term perspective. This will help to define new solutions for this crucial public health issue. We are responsible for prospective health economic data collection alongside the clinical part. While data are maturing, cost-of-illness studies, cost-effectiveness analyses and research on other topics are being planned.