Health Research Methods

Our goal is to develop (discovery), test (evaluation), and make available (implementation) research methods in the health research field.

 

  ocre  Discovery Science              ocre   Evaluation Science              blue  Implementation Science

 

COMBACTE Magnet: Antimicrobial resistance in ICU

Leonhard Held

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Bayesian variable and model selection techniques can be used to find a prediction model for mortality at the intensive care unit (ICU) by assessing the effect of hospital-acquired pneumonia (HAP) and other possible variables (age, patient characteristics at day of admission, patient characteristics during ICU stay) on mortality at the ICU.

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COMBACTE STAT-Net: Clinical trial design for antibiotics

Leonhard Held

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We develop novel clinical trial designs for the development of new antibiotic drugs.

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Evaluation of CD4 and CD8 as progression markers for HIV1 infection

Leonhard Held

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The project examines the relationship between CD4+ and CD8+ during HIV infection and the prognostic value of CD8+ additional to CD4+ for HIV disease progression.

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  Geographic variation in the utilisation of health care interventions: what is the role
of recommendations and other influences?
Matthias Schwenkglenks
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We study geographic variation in the healthcare for chronic diseases, related determinant with a special focus on clinical recommendations, and consequences.

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Hospital and nursing home stays in Switzerland

Matthias Bopp

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Besides health status, also socio-demographic and regional factors impact on medical care utilization in Switzerland – pointing to a substantial potential for reducing costs and improving patient's quality of life.

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M-HEALTH

Oliver Gruebner

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We work on providing big geo- social media data that will allow studies on health and social behaviour monitoring

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Model-Based Recursive Partitioning for Stratified Medicine

Torsten Hothorn 

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This project develops methods for inference on patient-specific treatment effects in the context of stratified medicine. 

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NISCI: Antibodies Against Nogo-A to Enhance Plasticity, Regeneration and Functional Recovery After Acute Spinal Cord Injury, a Multicenter European Clinical Proof of Concept Trial

Torsten Hothorn 

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We develop a statistical model for the conditional upper extremity motor score distribution in two-armed randomized clinical trials.

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Objective Bayesian model selection in generalized regression

Leonhard Held

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We aim to develop novel statistical methodology for objective Bayesian model selection in generalized regression models.

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PCORI: Benefit harm assessment methods for guidelines

Milo Puhan

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Through case studies, we will generate useful, evidence-based guidance to inform patient-centered care of people with multiple chronic conditions.

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SEDA: Sensitivity diagnostics for Bayesian hierarchical models

Malgorzata Roos

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SEDA project aims to develop and implement a novel two-component sensitivity diagnostic tool for Bayesian hierarchical models estimated by Stan, JAGS or INLA.

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Spatio-temporal modelling
of infectious diseases

Leonhard Held

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This research project aims to develop novel statistical methodology for both retro- and prospective analysis of space-time data on infectious disease incidence.

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SPLASHY -
Swiss Preschooler‘s Health Study

Susi Kriemler

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Pilot Study
This is a pilot study to evaluate the feasibility of a motor skill enhancing intervention in preschoolers.

Observational Study
This is an observational study to test the relation between physical activity and stress and important health outcomes such as motor skills, cognition, psyological health and obesity in preschoolers.

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Strengths and Limits of
Swiss Health Statistics

Matthias Bopp

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An intelligent combination of different data sources enables to overcome several known shortcomings of Swiss health statistics.

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SURFit: Effects of a 1-year partially supervised exercise programme in childhood cancer survivors – a randomized controlled trial

Susi Kriemler

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SURFit tests the effect of a 12-month partially supervised conditioning program in childhood cancer survivors using a randomized controlled trial.

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Swiss MS Registry -
Registry Development

Viktor von Wyl

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The Swiss MS Registry is a patient-centered, national research database that comprehensively documents aspects of MS that can impact an affected person's daily life, including social and medical data.

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Swiss National Cohort

Matthias Bopp

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The Swiss National Cohort (SNC) is a long-term, census-based, multipurpose cohort and research platform.

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Validation of two activity monitors (ActiGraph, activPAL) in the measurements of posture and motion in white-collar occupations

Holger Dressel

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This study compares the ActiGraph and activPAL activity monitors in the measurement of posture and motion in white-collar workers.

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