The project aims to examine the relationship between CD4+ and CD8+ during HIV infection and the prognostic value of CD8+ additional to CD4+ for HIV disease progression. This relationship will be examined in treatment naive patients as well as for patients after starting a highly active antiretroviral therapy (HAART). The influence of different treatment regimens on the CD4+ and CD8+ counts will be investigated. In order to answer these questions, an methodological framework will be developed which extends and applies existing methods for longitudinal data.
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