Exercise capacity is a strong predictor for mortality, exacerbations and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). Despite its importance, exercise capacity is rarely assessed outside of rehabilitation settings, mainly due to time, space and resources required of the well-established exercise tests. The 1-minute sit-to-stand (1-min STS) test is a promising exercise capacity test which is simple, easy to conduct and increasingly used in studies with COPD patients.
However, its learning effect, reliability, responsiveness to change and minimal important difference (MID) have not yet been established in COPD patients. Also, little is known about the physiological response to the test in terms of the cardiorespiratory stress that is elicited. The overall objective of the STAND-UP study is to provide an in-depth validation of the 1-min STS test in patients with COPD. Two main objectives will be addressed: 1) to assess the measurement properties of the 1-min STS test (namely the reliability, construct validity, responsiveness to change and MID), and 2) to explore the predictive properties of the 1-min STS test with regards to detecting exacerbations and to identify patterns of physical activity and patient-reported symptoms of exacerbations, i.e. important determinants of the clinical phenotypes of patients.
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