Immunogenicity and safety of live vaccines under immunosuppression

The study's primary objectives are the

  1. Comparison of viremia levels after yellow fever vaccination in travelers under low dose methotrexate therapy (≤20mg/ /week) and healthy travelers at short intervals after vaccination
  2. Comparison of yellow fever specific antibody levels after yellow fever vaccination in travelers under low dose methotrexate therapy (≤20mg/week) and healthy travelers at short intervals after vaccination

Secondary objectives

  1. Comparison of the percentage of individuals who develop quantitative antibody levels >0.7 LNI (>0.5 IU/ml) in both groups at short intervals after vaccination
  2. Safety assessment of yellow fever vaccination in both groups by studying adverse vaccine reactions

 

For more information and to participate please visit the project page.