PCORI: Benefit harm
assessment methods for guidelines

The majority of people with one chronic condition have multiple conditions, and care that focuses on one condition at a time is not patient-centered because patients and their families do not view each condition in isolation. Our existing evidence base fails to adequately inform patient-centered care of people with multiple chronic conditions (MCCs). Our objective is to perform research on methods to improve the validity of systematic reviews of patient-centered research for people with MCCs, and improve the translation of the knowledge in the systematic reviews into guidelines that can
be better used to inform patient-centered care for people with MCCs. Through case studies, we will generate useful, evidence-based guidance to inform patient-centered care of people with MCCs for two important clinical questions.