COPD is a systemic illness; morbidity and mortality due to this disease are on the increase, and it has great impact on patients’ lives. Most COPD patients are managed by general practitioners. The European Respiratory Society (ERS) and American Thoracic Society (ATS) call for COPD disease severity indices that better represent the clinical manifestations of COPD. Thus, our objectives are: (1) The development and validation of a practical COPD disease severity index to predict the course of health-related quality of life over time. (2) The validation of the ADO-Index (Age, Dyspnea, Obstruction) to predict 3-year mortality in COPD patients in primary care. (3) Link evidence on treatment effects to the COPD risk indices to guide COPD treatment selection.