Causal evidence from observational data regarding the effect of initial opioid dose concentration on adverse outcomes - a study based on the target trial emulation framework

The target trial emulation framework was used to feature a randomized controlled trial aiming at addressing the research questions whether there is a causal relationship between the initial opioid dose and adverse outcomes in younger patients with musculoskeletal disorders. Real-world data was used based on claims from Helsana insurance company. Primary outcome was a composite outcome of death, emergency department visit, and hospitalization in an acute hospital. Further outcomes were burden of analgesic use, recurring opioid treatment, and duration of opioid treatment.

The protocol of the study can be found on OSF: here
The study was initiated as a master thesis of the Biostatistics master program.