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Epidemiology, Biostatistics and Prevention Institute

Current classifications for COPD disease severity are limited, international cohort collaboration finds

Professor Milo Puhan is part of the international 3CIA initiative, which studies how to classify severity of COPD (Chronic Obstructive Lung Disease). A report by the 3CIA collaborators will appear in the June 2015 edition of The Lancet Respiratory Medicine. Based on 15,632 patients from 22 COPD cohorts in seven countries, 3CIA researchers found that current approaches for classification of COPD severity (GOLD 2007 and 2011) have limited value to accurately inform patients about their prognosis and to serve as basis for treatment selection.1 The 3CIA initiative extends previous work of the ADO collaboration established by Prof. Puhan.2 Looking forward, the 3CIA collaborators will build upon this previous work by developing and validating prognostic scores such as the ADO or BODE index. The aim is to provide better approaches for classification of COPD severity than GOLD 2007 and 2011. Prognostic scores represent a promising approach to explicitly inform patients with COPD about their risk of early death or acute deteriorations and to inform clinicians about appropriate treatment selection to improve patient outcomes.
1 Soriano et al. Lancet Respir Med 2015
2 Puhan et al. BMJ Open 2012